AZD4547

Chemical Information
Product Name AZD4547 CAS No. 1035270-39-3
Molecular Weight 462.56398 Molecular Formula C26H32N5O3
MOQ 10g Brand Biolang

Product Description

AZD4547 is a novel and selective inhibitor of the fibroblast growth factor receptor (FGFR) 1, 2, and 3 tyrosine kinases. It potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, and 3 in vitro with IC50 values of 0.2, 2.5, and 1.8 nM, respectively. In cells, it inhibited autophosphorylation of FGFR1, 2, and 3 tyrosine kinases with IC50 values of 12, 2, and 40 nM, respectively. It had potent antitumor activity against FGFR-deregulated tumors in preclinical models. Gavine, P.R., et al. "AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family." Cancer Res. 72: 2045-2056 (2012).

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About Biolang

Shanghai Biolang Bio-Tech Co., Ltd., founded in 2004, located in Shanghai and Nanjing, R&D and logistics center located in Wuhan National Bioindustry Base,the production base in Luotian, Tongshan, Dongying, Pingxiang.Biolang is specialized manufacturer and supplier of New-Type pharmaceutical Raw Materials and Pharmaceutical Intermediates.