|Product Name||AZD4547||CAS No.||1035270-39-3|
|Molecular Weight||462.56398||Molecular Formula||C26H32N5O3|
AZD4547 is a novel and selective inhibitor of the fibroblast growth factor receptor (FGFR) 1, 2, and 3 tyrosine kinases. It potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, and 3 in vitro with IC50 values of 0.2, 2.5, and 1.8 nM, respectively. In cells, it inhibited autophosphorylation of FGFR1, 2, and 3 tyrosine kinases with IC50 values of 12, 2, and 40 nM, respectively. It had potent antitumor activity against FGFR-deregulated tumors in preclinical models. Gavine, P.R., et al. "AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family." Cancer Res. 72: 2045-2056 (2012).