|Product Name||BAR 501||CAS No.||1632118-69-4|
|Molecular Weight||406.64||Molecular Formula||C26H46O3|
BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM.
BAR501 is a selective GPBAR1 agonist devoid of FXR agonistic activity. It effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with an EC50 of 1 μM. Exposure of GLUTAg cells to BAR501 (10 μM) increases the expression of GLP-1 mRNA by 2.5 folds