|Product Name||BEC HCl||CAS No.||222638-67-7|
|Molecular Weight||229.49||Molecular Formula||C5H13BClNO4S|
BEC HCl is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM (ph 7.5). target: Arginase II; In vitro: BEC HCl causes significant enhancement of NO-dependent smooth muscle relaxation in this tissue. BEC HCl enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and lead to further increases in airways hyperresponsiveness. In vivo: BEC HCl increased contractility in isolated myocytes from WT and NOS3 but not NOS1 knockout mice.