EPZ6438

Chemical Information
Product Name EPZ6438 CAS No. 1403254-99-8
Molecular Weight 572.73756 Molecular Formula C34H44N4O4
MOQ 100g Brand Biolang

Product Description

EPZ-6438 inhibits the activity of human PRC2-containing wild-type EZH2 with Ki of 2.5±0.5 nM.
EPZ-6438 inhibits EZH2 in a manner competitive with the substrate S-adenosylmethionine (SAM). EPZ-6438 inhibits EZH1, EZH2(in peptide assay), EZH2 (in nucleosome assay) with IC50of 392 nM, 11 nM and 16 nM, respectively. EPZ-6438 displays a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs tested.

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About Biolang

Shanghai Biolang Bio-Tech Co., Ltd., founded in 2004, located in Shanghai and Nanjing, R&D and logistics center located in Wuhan National Bioindustry Base,the production base in Luotian, Tongshan, Dongying, Pingxiang.Biolang is specialized manufacturer and supplier of New-Type pharmaceutical Raw Materials and Pharmaceutical Intermediates.