|Product Name||GW4064||CAS No.||278779-30-9|
|Molecular Weight||542.84||Molecular Formula||C28H22Cl3NO4|
GW 4064 is a potent FXR agonist with EC50 of 65 nM.
Treatment with different concentrations of GW4064 (1, 2.5, 5, 10 μM) reduces the lipid accumulation in the cells. Concordantly, GW4064 treatment significantly represses oleic acid-induced CD36 protein levels in a dose-dependent manner. Taken together, these data indicate that prevention of hepatic lipid accumulation is likely due to an inhibition of Cd36 expression by long-term GW4064 treatment.